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RNAseq and functional metabolic analyses revealed a fundamental immunometabolic reprogramming in response to ketones favoring mitochondrial oxidative metabolism. Overall it looks like a high fat, ketogenic diet seems supportive to the immune response helping in the proliferation capability and survival/efficacy in challenging environments. The consistent lchf reveals the overall efficiency of the fourth-generation environment. If they are shown to take up BHB then it could be a very effective way to continue that efficiency against cancer. 10. Monocytes-turned-macrophages are part of our immune system and present throughout our body. 11. The SARS-COV-2 spike protein anti-bodies are prolonged in the body because the ketone body beta-hydroxybutyrate attaches to its free lysine. The result is that these cells are able to divert energy towards glycogen, which is the stored form of glucose. Teff cells preferentially use KBs over glucose to fuel the tricarboxylic acid (TCA) cycle in vitro and in vivo. Teff cell IFN-γ production and cytolytic activity.